Practical and ethical dilemmas in the clinical testing of microbicides: a report on a symposium

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Describes microbicides, substances that would reduce the transmission of sexually transmitted infections (STIs) when used vaginally or rectally. Summarizes extensive deliberations, key decisions and recommendations made at a 1997 symposium of 55 advocates, scientists, policy makers, and industry representatives from 15 countries across Africa, Asia, Latin America, Europe, and the United States. Addresses such complex issues as informed consent, standard of care, community participation, the role of social science, and implications for public policy.